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Nordic Life Science - issue 4 2020 - E-magin - Tulo

A common denominator in all indications is the great potential to counteract the often fatal hyperinflammation that […] SynAct Pharma AB today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company's lead candidate drug AP1189 in adults diagnosed with COVID-19 and with AP1189 –a melanocortin receptor agonist to reduce inflammation and “boost” healing First indication: activeinflammatory joint diseases (rheumatoid and psoriatic arthritis) Opportunity: additional indications based on Mode of Action (ACTH-like properties) 2020-06-30 · AP1189 Study. The Phase II study for AP1189 will be double-blind, multi-center, and placebo-controlled. In the study, AP1189 will be examined as a potentially additional therapy for patients with idiopathic membranous nephropathy who have nephrotic syndrome. A multicenter, two-part, randomized, double-blind, placebo-kontrolled, 4-week study with repeated doses of AP1189. The study population will consist of newly diagnosed subjects with severe active Rheumatoid Arthritis, defined with a Clinical Disease Activity score (CDAI) > 22, who are to start up-titration with methotrexate. SynAct Pharma has announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). The patients will be enrolled at medical centers in Brazil… AP1189 or placebo is dosed once daily for 4 weeks in parallel with the initiation of a treatment with the disease-modulating, anti-rheumatic drug methotrexate (MTX).

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Klinisk prövning på Reumatoid artrit: 50 mg AP1189, AP1189

Dagens Nyheter SynAct stärker IP-portföljen och får "Intention to Grant" från Europas patentverk för ett centralt patent som täcker AP1189 - SynAct Nynet, The trial design, which has been approved by the authorities in Brazil, is based upon scientific evidence supporting the role of AP1189 in modulating inflammatory responses. SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). The mechanism of action of SynAct Pharma´s lead compound AP1189 is to promote resolution of inflammation through melanocortin receptor activation directly on macrophages, thereby reducing the pro-inflammatory activity of macrophages and by stimulating so-called macrophage efferocytosis, a specific ability to clear inflammatory cells (J Immun 2015, 194:3381-3388).

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SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS).

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Find their customers, contact information, and details on 58 shipments. SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). The patients will be enrolled at medical centers in Brazil and in a collaboration between SynAct Pharma, Queen Mary I am indeed happy that we have started the second phase of the study to investigate whether AP1189 can promote inflammatory resolution and thereby reduce time to recovery and reduce the risk of development of severe ARDS,” said primary investigator Prof.
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